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Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure

RecruitingNAAges 18 Years - anyAllUniversity Health Network, Toronto
NCT04524585 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

PNEUMA is a preliminary safety and feasibility trial of a novel approach to the titration of neuromuscular blockade (NMB) to safe spontaneous breathing in patients with moderate to severe acute hypoxemic respiratory failure (AHRF) supported with invasive mechanical ventilation.

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📋 Eligibility rules (as published)
Inclusion Criteria: Patients supported on invasive mechanical ventilation for moderate to severe AHRF (PaO2/FiO2 \< 150 mm Hg or FiO2 ≥ 60% with an SpO2 ≤ 97% or receiving venovenous extracorporeal membrane oxygenation) Exclusion Criteria: 1. Contraindication to neuromuscular blockade (allergy, history of malignant hyperthermia) 2. Contraindication to ulnar nerve stimulation (bilateral peripheral neuropathy, skin burns on both wrists) 3. Previous history of a formally diagnosed neuromuscular disorder
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What it tests

  • Cisatracurium
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Where

1 site
University Health Network
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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