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Dissecting Host-microbiome Modifiers of Type 2 Diabetes Risk

RecruitingNAAges 18 Years - 60 YearsAllLaval University
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In plain words

What the trial is, and whether it could suit you

It is now well documented that changes in gut microbiota composition accompany obesity and type 2 diabetes (T2D) and contribute to low-grade inflammation, insulin resistance,and glucose intolerance. It is not yet clear if T2D predisposes the intestine to allow more microbial products or possibly live bacteria to subvert the gut mucosal barrier. However, it is known that hyperglycemia during T2D induces a more permissive gut barrier allowing increased penetration of microbes and their products into the blood. An important next step is to determine which strains of bacteria promote dysbiosis, allowing bacteria or bacterial components to subvert the gut barrier and alter glucose control. It is hypothesized that gut microbes in the colon and other lower gut segments are key modulators of energy balance, glucose homeostasis and insulin sensitivity.

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📋 Eligibility rules (as published)
Inclusion Criteria: * T2DB de novo or non T2DB patients Exclusion Criteria: * oral hypoglycemic agents or lipidlowering or antihypertensive drugs
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What it tests

  • Endoscopy and duodenal biopsy and sampling
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Where

1 site
INAF, Université Laval
Québec, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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