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Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers

Recruitingn/aAges 16 Years - anyAllWestern University, Canada
NCT04616313 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed. * Male and female participant age ≥16 years. * Participant has recently started vaping, \>1 and \<5 years weekly use. * 70 participants will be c-cigarette never users. * 70 participants will be former or current c-cigarette users. * 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls. Exclusion Criteria: * Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia. * Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material. * Participant unable to perform spirometry or plethysmography maneuvers.
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What it tests

  • Hyperpolarized Xenon-129 MRI of the lungs
  • Computed Tomography (CT)
  • Pulmonary Function Tests (PFT)
  • Cardiopulmonary exercise testing (CPET)
  • Sputum analysis
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Where

1 site
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
London, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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