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Low or High Botox Dilution for the Hemiplegic Gait?

RecruitingPhase 1Ages 18 Years - anyAllUniversity of Ioannina
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In plain words

What the trial is, and whether it could suit you

There is debate regarding the efficiency of different dilutions of Botulin toxin type A (BTX-A) injections. Some authors believe that highly diluted BTX-A injections achieve greater neuromuscular blockade resulting in higher spasticity reduction. On the other hand, other researchers suggest that there is no difference in spasticity decrease if either high or low volume toxin is being injected. Studies on this subject lack either the design or the power of study was low. Therefore, there is no clear guideline for an optimal botulinum toxin dilution protocol. In an attempt to have a better understanding, a cross over study was designed. The material will be patients with spastic hemiparesis which will be treated with Botulin toxin at different dilutions. Gait analysis will be used for the evaluation of the Botulin toxin injection on gait improvement. To the best of our knowledge such a tri

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * equinovarus deformity * with an average 3 on Ashworth spasticity scale * able to walk indoors either freely or with a cane. Exclusion Criteria: * patients suffering from any mental illness that would disturb the gait pattern * patients suffering from musculoskeletal diseases that overtly interfere with the gait
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What it tests

  • Botulinum toxin
  • gait analysis
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Where

1 site
Department of Physical Medicine and Rehabilitation, University Hospital of Ioannina
Ioannina, Greece
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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