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Postnatal Steroids Effects on Cardiac Function in Extremely Preterm

Recruitingn/aAges 1 Minute - anyAllMcGill University Health Centre/Research Institut…
NCT04644094 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects before and after dexamethasone administration on cardiac structure/performance will be evaluated by using the M-mode technique (Devereux method (25-27) and lung water content will be specifically determined by the degree of water retention in premature lungs assessed by lung ultrasound at the pre specified time points. Methodology / Study design Single center, prospective observational cohort study planning to enroll eligible patients over a period of 12 months

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📋 Eligibility rules (as published)
Inclusion Criteria: * \< 29 weeks of gestational age at birth admitted at the McGill University Children Hospital's neonatal intensive care unit * To be initiated on dexamethasone therapy for treatment of significant lung disease as per medical team decision. Exclusion Criteria: * Congenital heart disease (except: Atrial septum defect (ASD), Ventricular septum defect (VSD) * Major congenital anomalies/genetic disorder (Trisomy 13, 18, 21) * Congenital severe lung or airway malformation (Trachea-esophageal fistula, congenital pulmonary airway malformation, congenital diaphragmatic hernia) * Twin-twin transfusion syndrome
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What it tests

  • Echocardiography (ECHO) and lung ultrasound (LUS) studies before and after Dexamethasone administration
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Where

1 site
Montreal Children's hospital, Mcgill University Health Centre
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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