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Localizing Epileptic Networks Using MRI and iEEG

RecruitingEARLY Phase 1Ages 18 Years - anyAllUniversity of Pennsylvania
NCT04649008 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with medication-refractory epilepsy * Planned intracranial EEG (IEEG) placement * Hypothesized to have temporal lobe epilepsy Exclusion Criteria: * Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)
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What it tests

  • 3T Magnetic Resonance Imaging
  • Intracranial electroencephalography recordings
  • 7T Magnetic Resonance Imaging
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Where

1 site
University of Pennsylvania
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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