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Hyperpolarized Xenon-129 MR Imaging of the Lung

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllUniversity of Virginia
NCT04662658 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to those of human COPD. Recently, "spiked" vape juice has been linked to severe lung damage. Unfortunately, the effects of e-cigarettes on the human lungs are still poorly understood, especially in healthy young adults. Therefore, establishing the health effects of e-cigarettes in humans is of paramount importance to guide medical and regulatory decision making. Its widespread use and immense popularity among teenagers and young adults have caused major concern given potentially significant addictive and detrimental long-term health effects.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Male and female subjects 21-30 years of age 2. At baseline health with no recent illnesses or medical conditions that would preclude enrollment as assessed by the Principal Investigator 3. Ability to understand a written informed consent form and comply with the requirements of the study. 4. E-cigarette use for more than 6 months preceding the date of enrollment and less than a 5 pack year smoking history (e-cigarette users) OR less than a 5 pack year smoking history (non-smoker group). 5. No diagnosis of any lung disease (pre-bronchodilator FEV1/FVC normal on the day of screening defined by \> 95thCI of NHANES III, ATS/ERS guideline) Exclusion Criteria: 1. History of any lung disease 2. Control (non-smoking) group: History of illegal drug use by inhalation 3. History of CNS disease including stroke and dementia, end-stage liver disease, coronary artery disease, renal failure 4. Acute infection of any kind in the previous 6 weeks 5. Pregnancy or a possibility of pregnancy 6. Anemia 7. Inability to undergo MR imaging based on the standard clinical criteria for MRI
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What it tests

  • Hyperpolarized Xenon -129 MRI
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Where

1 site
Snyder Building 480 Ray C. Hunt Drive
Charlottesville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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