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Exploratory Study of Clonal Evolution in Cancer for Patients Undergoing Transoral Robotic Surgery for Radiation Exposed Residual/reCurrent Tumours of the Upper Aerodigestive Tract

Recruitingn/aAges 19 Years - anyAllRoyal Marsden NHS Foundation Trust
NCT04671940 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Radical radiotherapy for head and neck squamous cell cancer (HNSCC) can be administered to primary disease with curative intent. Residual disease, recurrence or further tumours may subsequently occur in this irradiated field. It is unknown whether these cancers reflect primary resistance or represent the evolution of resistance on treatment. Understanding this could allow stratification of patients to more effective primary treatments, such as transoral robotic surgery, or help tailor systemic therapies for these cancers in previously irradiated fields. RECUT+ is an exploratory molecular analysis study to assess the selective impact of radiation therapy on HNSCC. Participants will be recruited from the Royal Marsden Hospital (RMH), Chelsea, a tertiary referral H\&N cancer unit in London, UK, specialising in transoral robotic surgery. Retrospective participants will be identified from

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📋 Eligibility rules (as published)
Inclusion criteria * Aged over 18 * Previous H\&N cancer treated with radiotherapy. * Undergoing TORS as part of their management for residual, recurrent or new primary H\&N cancer. Exclusion criteria * Where TORS is used in a diagnostic setting only * Nasopharyngeal and thyroid head and neck cancers * Where no tissue specimens are available from the recurrent/residual/secondary tumour for the retrospective cohort
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What it tests

  • DNA Analysis
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Where

1 site
The Royal Marsden Hospital
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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