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iCorMicA - Stratified Medicine in Angina

RecruitingNAAges 18 Years - anyAllNHS Greater Glasgow and Clyde
NCT04674449 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥18 years. 2. A clinical plan for invasive coronary angiography. 3. Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires. 4. Able to comply with study procedures. 5. Able to provide informed consent. Exclusion Criteria: 1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure). 2. History of coronary artery bypass surgery. 3. Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*. 4. Logistical reason\*. \*These patients will enter a follow-up registry.
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What it tests

  • Disclosure of IDP results
  • IDP performed but results not disclosed
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Where

39 sites
Mater Private Hsopital
Cork, Ireland
Mater Private Hospital
Dublin, Ireland
Radboud University Medical Centre
Nijmegen, Netherlands
5th Military Hospital
Krakow, Poland
Golden Jubilee National Hospital
Clydebank, United Kingdom
Aberdeen Royal Hospital
Aberdeen, United Kingdom
William Harvey Hospital
Ashford, United Kingdom
Basildon University Hospital - Essex Cardiothoracic Centre
Basildon, United Kingdom

…and 31 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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