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Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

RecruitingPhase 2Ages 45 Years - anyAllStanford University
NCT04676802 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the efficacy of a combination of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen and acetaminophen, in comparison to a morphine analogue substance (oxycodone) for pain management in the first 30 days after surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Undergoing trapeziectomy for thumb osteoarthritis English proficient, Exclusion Criteria: * Pregnancy Current use of opioids Concurrent surgeries (ex. trapeziectomy combined with carpal tunnel release) Inability to complete study forms (education, cognitive ability, mental status, medical status) Allergy or intolerance to Ibuprofen, Acetaminophen and/or Oxycodone Liver or kidney dysfunction, abnormal liver enzymes restricting use of acetaminophen or ibuprofen History of chronic heart failure, upper gastrointestinal bleeding or coagulopathy History of complex regional pain syndrome
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What it tests

  • NSAID capsules
  • Opioid capsule
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Where

2 sites
Stanford Health Care
Redwood City, United States
University of Utah Health Care
Salt Lake City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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