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Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer

RecruitingNAAges 18 Years - anyAllTechnische Universität Dresden
NCT04678583 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

the ARMANI trial will test the hypothesis, if an anatomic resection (AR) improves long-term outcome vs. a non-anatomical resection (NAR) in patients undergoing surgery for RAS-mutated colorectal liver metastasis (CRLM).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Colorectal cancer with RAS mutation (KRAS or NRAS) * Colorectal liver metastases (single or multiple) * Planned R0 resection of liver metastases (and primary tumor, if present) * Anatomical and non-anatomical liver resection technically feasible * Male and female patients, age ≥ 18 years * Written informed consent Exclusion Criteria: * Extrahepatic metastases * Planned staged liver resection (e.g. two-stage hepatectomy) * Diagnosis of another cancer \< 5 years prior to randomization Exceptions: curatively treated in situ cervical cancer, curatively resected non-melanoma skin cancer * Expected lack of compliance * Addiction or other illnesses which do not allow the person concerned to assess the nature and extent of the clinical trial and its possible consequences
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What it tests

  • Resection of colorectal liver metastases
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Where

37 sites
Department of Surgery at the University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University
Mannheim, Germany
Department of Gastrointestinal-, Thoracic and Vascular Surgery University Hospital Carl Gustav Carus Technische Universität Dresden
Dresden, Germany
Intestinal Center West Middle Franconia, ANregiomed Clinic Ansbach
Ansbach, Germany
Clinic for General, Vizeral and Transplant Surgery, Augsburg University Hospital
Augsburg, Germany
Department of General, Visceral and Vascular Surgery, Charité, University Medicine Berlin, Campus Benjamin Franklin Berlin
Berlin, Germany
Clinic and Polyclinic for General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn
Bonn, Germany
Surgical Clinic, Municipal Hospital Braunschweig gGmbH
Braunschweig, Germany
Cancer Center, Helios Amper-Hospital Dachau
Dachau, Germany

…and 29 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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