AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Comparison of Two sTRAtegies For the Non-Invasive Diagnosis of advanCed Liver Fibrosis in NAFLD

RecruitingNAAges 18 Years - 80 YearsAllUniversity Hospital, Angers
💬

In plain words

What the trial is, and whether it could suit you

NAFLD, closely linked to overweight and insulin resistance, has reached 25% prevalence worldwide. Advanced liver fibrosis(ALF) must be accurately diagnosed in NAFLD because it defines a subgroup of patients with impaired prognosis, and these patients need a specific management to prevent the occurrence of liver-related complication. Relatively few NAFLD patients develop ALF and it is a challenge for physicians to identify them. Liver biopsy is the reference for liver fibrosis evaluation but this invasive procedure cannot be first-line used in NAFLD. Non-invasive diagnosis of liver fibrosis is now available, especially liver stiffness measurement (LSM) with Fibroscan and blood fibrosis tests. However, Fibroscan is a costly device available only in few specialized centres with thus poor accessibility in face of the large NAFLD population. Blood fibrosis tests can be performed by every phy

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: 1. Presence of NAFLD as defined by : * The presence of liver steatosis as assessed by ultrasonography (bright liver) or magnetic resonance imaging/spectroscopy (fat fraction \>5.6%) or Controlled Attenuation Parameter (≥248 dB/m) * The absence of steatosis-inducing drugs (systemic corticosteroids, methotrexate, amiodarone, tamoxifen) * The absence of excessive alcohol consumption (\<210 g/week in men or \<140 g/week in women) * The absence of other causes of chronic liver disease (chronic viral hepatitis B or C, hemochromatosis, auto-immune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, Wilson disease alpha-1-antitrypsin deficiency). 2. Age ≥18 years and ≤80 years 3. Affiliated person or beneficiary of a social security regime 4. Written informed consent of the patient who agree to comply with the study protocol. Exclusion Criteria: 1. Decompensated cirrhosis (ascites, variceal bleeding, hepatic encephalopathy, liver failure, hepato-renal syndrome) 2. Hepatocellular carcinoma 3. Inability to safely undergo liver biopsy 4. Participation in other intervention study with drug protocol treatment in progress at the time of inclusion or within one month prior to inclusion in the study. 5. Pregnant, breastfeeding or parturient woman 6. Person restricted by judicial or administrative decision 7. Person under psychiatric care under restraint 8. Person subject to a legal protection measure 9. Person unable to express consent
💊

What it tests

  • blood tests
📍

Where

20 sites
University Hospital of Angers
Angers, France
University Hospital of Besançon
Besançon, France
Avicenne Hospital (Greater Paris University Hospitals)
Bobigny, France
University Hospital of Dijon
Dijon, France
Departemental Hospital Center of Vendée
La Roche-sur-Yon, France
University Hospital of Grenoble
La Tronche, France
University Hospital of Lille
Lille, France
University Hospital of Limoges
Limoges, France

…and 12 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy