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Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.

RecruitingPhase 2Ages 18 Years - 65 YearsAllInstitute of Hematology & Blood Diseases Hospital…
NCT04688736 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a prospective, randomized, double-blind controlled trial to evaluate the efficacy of placebo versus chlorpheniramine for the prevention of allergic transfusion reactions.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18\~65 years old. * Subject is diagnosed with hematological disorder and requires blood product (i.e. suspended red blood cells, apheresis platelets, fresh frozen plasma) transfusions. * Subject can fully understand and voluntarily sign informed consent forms. Exclusion Criteria: * Subject with a history of allergic diseases. * Subject experienced at least 1 moderate/severe or 2 mild allergic reactions in the past. * Subject received glucocorticoid or allergy drugs within 24 hours before blood transfusion. * Subject transfused with washed RBC. * Received allo-HSCT transplantation before. * Subject with heart failure. * Subject suffered from sequelae of cardiovascular or cerebrovascular diseases. * Pregnant or nursing women. * Inability to understand or to follow study procedures.
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What it tests

  • Placebo
  • Chlorpheniramine
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Where

4 sites
Anhui Provincial Hospital
Hefei, China
Zhoukou Central Hospital
Zhoukou, China
The Second Affilated Hospital of Shandong First Medical University
Tai’an, China
Regenerative Medicine Center
Tianjin, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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