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Donor CHIP and Allogeneic HSCT Outcome

Recruitingn/aAges 18 Years - anyAllThe University of Hong Kong
NCT04689750 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Current data on the impact of donor CHIP on long-term recipient outcome remain largely speculative. Data on the impact of donor CHIP including on allograft function, immunologic dysfunction, graft versus host disease (GVHD), disease relapse and survival across various donor populations are scarce. This is a retrospective-prospective cohort study designed to determine the association between donor gene mutations and outcome following allogeneic HSCT.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adult aged 18 year or above 2. Donor and recipient of allo-HSCT 3. In prospective and partial prospective/retrospective case, subjects who have provided a signed written informed consent. In retrospective case, subjects who had provided a previously signed written informed consent on: 1. voluntary provision of clinical data, and 2. voluntary provision of archived/remaining specimens for genetic analysis, and 3. authorizing storage and usage of archived/remaining specimens for any further analysis Exclusion Criteria: 1\. Autologous peripheral blood stem cells or bone marrow stem cell donors for autologous HSCT
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What it tests

  • Next generation sequencing
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Where

1 site
The University of Hong Kong
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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