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TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

RecruitingPhase 2Ages 18 Years - anyAllTeclison Ltd.
NCT04701476 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with refractory metastatic colorectal cancer or non-small cell lung cancer with liver metastasis treated with Trans-arterial Tirapazamine Embolization along with Pembrolizumab.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Liver metastatic MSS-mCRC or NSCLC without EGFR or AKT mutations * mCRC progressed on at least two lines of standard chemotherapy; or * NSCLC progressed on chemotherapy and an immune checkpoint inhibitor * Measurable disease * ECOG 0-1 * At least 4 weeks from prior chemotherapy and free from chemo-related toxicity * Adequate organ function Exclusion Criteria: * Prior organ transplantation * Liver metastasis more than 50% * Oxygen saturation less than 92% in room air * Prior autoimmune disorder * CNS metastasis * Major GI bleeding in the last 2 months
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What it tests

  • TATE and pembrolizumab
  • TAS-102 pill
  • Regorafenib Pill
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Where

3 sites
University of California, Irvine Medical Center
Orange, United States
China Medical University Hsinchu Hospital
Hsinchu, Taiwan
Chung Shan Medical University Hospital
Taichung, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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