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Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Clermont-Ferrand
NCT04701749 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The etiology of the radiation cystitis is a pelvic irradiation generally performed as part of the treatment of prostate cancer. The incidence is 50,000 new cases per year. Approximately 35% of prostate cancer treatment is radiotherapy. The prevalence of haematuric radiation cystitis is 4-5% (about 800 patients). One of the complications of radiation cystitis is persistent hematuria. There is currently no curative treatment for this hematuria. There are few treatment options with a random probability of improvement of this symptomatology. These haematurias are rarely resolved spontaneously and most of the time involve emergency room management with +/- invasive procedures, sometimes by hospitalisation, always with a significant psychological impact on the patient. Furthermore, lifetime anticoagulant treatment considerably increases the likelihood of bladder bleeding. This is the case of

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient over 18 years old benefiting a social security sheme. * Patient with hematuric radiation bladder associated with a non valvular anticoagulated atrial fibrillation. Exclusion Criteria: * All the other hematuria's reasons * Other reason of anti platelet agent using than atrial fibrillation
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What it tests

  • Percutaneous left atrial closure
  • No Percutaneous left atrial closure
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Where

1 site
Chu Clermont Ferrand
Clermont-Ferrand, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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