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Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel Defects

Recruitingn/aAges 8 Years - 55 YearsAllAssistance Publique - Hôpitaux de Paris
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In plain words

What the trial is, and whether it could suit you

The study focuses on the analysis of enamel defects grouping together hypomineralization and hypoplasia. It focuses on 3 very characteristic enamel pathologies that are most often encountered in dental consultations: Molar Incisor Hypomineralization (MIH), dental fluorosis (FD) and amelogenesis imperfecta (AI). The research focuses on the use of a spectrophotometer for measuring tooth colors: the Zfx SpectroShade® (MHT) and its software as a means of early diagnosis of pre-eruptive enamel abnormalities. The main objective of the study is to analyze the color parameters of teeth affected with one of the 3 enamel abnormalities for use of the spectrophotometer as a non-invasive diagnostic tool for enamel defects. The secondary objective is focused on the biological, structural and physicochemical characterizations of these different enamel pathologies from extracted teeth or enamel biopsie

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
For patients : Inclusion Criteria : 1. Age between 8 and 55 years old 2. Carrier of one of the following 3 quantitative pre-eruptive enamel anomalies : AIH, dental fluorosis or MIH 3. Information and collection of the non-opposition of the adult patient or of the representative(s) of parental authority present for the minors. Criteria for non-inclusion : 1. Pregnant or breastfeeding woman 2. Under guardianship or curators 3. Opposition of the minor patient 4. Presenting pre-eruptive anomalies only on the molars (the spectrophotometer can only take pictures of the anterior dental sector (incisors and canines)). 5. Other types of hypomineralization (post-eruptive, of traumatic or infectious origin, idiopathic). 6. Having undergone radiotherapy or chemotherapy inducing dental and periodontal damage. 7. Having systemic abnormalities (unbalanced diseases), haemochromatosis, porphyria 8. Under medication likely to disturb the coloring of the teeth For witnesses : Inclusion Criteria : 1. Age between 8 and 55 years old 2. Information and collection of the non-opposition of the adult witness or of the representative(s) of parental authority present for the minors. 3. Free of any anomaly of tooth structure, exogenous dyschromia and carious lesions. Criteria for non-inclusion : 1. Pregnant or breastfeeding woman 2. Under guardianship or curators 3. Opposition of the minor witness 4. Carrier of a quantitative pre-eruptive enamel anomaly 5. Polycarpus (preventing the diagnosis of amyl hypomineralization)
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What it tests

  • spectrophotometer
  • Biological (protein analysis by western blot or mass spectrometry of matrix proteins), structural (electron microscopy) and physico-chemical analyses
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Where

1 site
Service d'odontologie, Hôpital Pitié-Salpêtrière
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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