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Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury

Recruitingn/aAges 18 Years - anyAllDr. Gordon Boyd
NCT04722939 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality. KRT has been linked to poor neurocognitive outcomes, leading to a reduced quality of life, as well as increased utilization of healthcare resources. Adults initiated on dialysis in the ICU may be particularly at risk of neurocognitive impairment, as survivors of critical illness are already predisposed to developing cerebrovascular disease and cognitive dysfunction over the long-term relative to healthy controls. Regional cerebral oxygen saturation (rSO2) may provide a critical early marker of long-term neurocognitive impairment in patients in this population. The INCOGNITO-AKI study aims to understand cerebral oxygenation in patients undergoing KRT, either continuous or intermittent, in

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📋 Eligibility rules (as published)
Inclusion Criteria: * age greater than or equal to 18 years * admitted to the Kingston Health Sciences Intensive Care Unit * diagnosis of severe AKI requiring Kidney Replacement Therapy (KRT) (defined by the presence of either a twofold increase in serum creatinine from baseline, serum creatinine level greater than or equal to 354 micromol/L with an increase of 27 micromol/L from baseline, or urine output \<6 mL/kg in the preceding 12 hours) * within 12 hours of initiation of KRT via intermittent hemodialysis (iHD) or continuous kidney replacement therapy (CKRT). Exclusion Criteria: * acquired or congenital neurological disorders * any contraindication to testing with cerebral oximetry, Kinarm, or MRI (e.g., claustrophobia, limb amputation, paresis, neuromuscular disorders, etc.) * KRT via PD * failure to consent * life expectancy less than 24 hours * clinical suspicion of renal obstruction * rapidly progressive glomerulonephritis or interstitial nephritis * prehospitalization eGFR \<30 mL/min/1.73m2.
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What it tests

  • Cerebral oxygenation
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Where

1 site
Kingston Health Sciences Centre
Kingston, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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