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The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

RecruitingNAAges 18 Years - anyAllMassachusetts General Hospital
NCT04737200 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult male or non-pregnant female volunteers (age 18+) * Scheduled for a cardiac surgical procedure with planned post-operative admission to the ICU for \>48 hours * Able and willing to give consent and comply with study procedures Exclusion Criteria: * Blind, deaf or unable to speak English * Women who are pregnant or nursing * Contraindications to safe use enteral nutrition, including gastrointestinal obstruction * Personal history of intestinal malabsorption, gallbladder disease or pancreatitis * Dietary restrictions precluding enteral feeds * Renal and liver failure requiring dialysis or Child-Pugh score \> 7 * Severe deficit due to structural or anoxic brain damage * With skin condition that precludes wearing sensors
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What it tests

  • Time-of-day of enteral nutrition provision (daytime first)
  • Time-of-day of enteral nutrition provision (nighttime first)
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Where

1 site
Massachusetts General Hospital
Boston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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