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Immediate Versus Late Placement

RecruitingNAAges 18 Years - anyAllUniversity Ghent
NCT04741607 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients in need of a single implant in the premaxilla will be invited to participate in this multicenter randomized controlled trial (RCT). Prior to surgery, a small-field low-dose cone beam computed tomography (CBCT) is taken to verify the integrity of the facial bone wall and an adequate amount of apical and palatal bone dimensions. Sixty patients will be randomly allocated to the test group or control group in 6 centers. Each center receives 10 sealed envelopes (5 are internally labelled with 'delayed implant placement' and 5 with 'immediate implant placement'). For each patient a digital planning is performed in implant planning software and a tooth-supported surgical guide is fabricated prior to tooth extraction. In the control group, alveolar ridge preservation is performed following tooth extraction. After a healing period of 4 months, a single implant is installed. In the tes

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📋 Eligibility rules (as published)
Inclusion Criteria: * at least 18 years old * good oral hygiene defined as full-mouth plaque score ≤ 25% (O'Leary et al. 1972) * presence of a single-rooted tooth in the anterior maxilla (15-25) that needs to be extracted for any reason with at least one neighboring tooth present * at least 3 mm bone available at the apical or palatal aspect of the alveolus to ensure primary implant stability * intact or nearly intact buccal bone wall at the time of extraction (max 3 mm bone missing = max 6 mm distance from free gingival margin to buccal bone crest) Exclusion Criteria: * systemic diseases * smoking * untreated periodontal disease * untreated caries lesions
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What it tests

  • Implant placement (BLX implant system, Straumann, Basel, Switzerland)
  • Ridge preservation (Bio-Oss Collagen 250 mg, Geistlich Pharma AG, Wolhusen, Switserland)
  • Socket seal (Mucograft Seal, Geistlich Pharma AG, Wolhusen, Switserland)
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Where

2 sites
Ghent University
Ghent, Belgium
UCL St Luc
Liège, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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