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Ticagrelor De-escalation Strategy in AMI Patients

RecruitingPhase 4Ages 19 Years - 80 YearsAllDong-A University
NCT04755387 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

DAPT de-escalation strategies to reduce bleeding include de-escalation of DAPT intensity (downgrading from potent P2Y12 inhibitor at conventional doses to either clopidogrel or reduced-dose prasugrel) or abbreviation of DAPT duration. The EASTYLE trial will evaluate a hybrid DAPT de-escalation strategy (reduced-dose ticagrelor, followed by aspirin early discontinuation) in AMI patients, compared with a conventional DAPT strategy.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Diagnosis with acute myocardial infarction. * Age โ‰ฅ19 year-old * Successful PCI with ultrathin bioresorbable polymer sirolimus-eluting stents (Orsiro; Biotronik AG). * Provision of informed consent. Exclusion Criteria: * Any prior event of hemorrhagic stroke or ICH. * Active bleeding (e.g., GI bleeding, ICH) or high-risk of serious bleeding. * Bleeding diathesis or coagulopathy (e.g., hemoglobin โ‰ค 10 g/dL or platelet count \< 100,000/ฮผL, bleeding needing transfusion within 30 days, and so on). * Allergy to stent metal, contrat media, and antiplatelet regimens. * Moderate to severe hepatic dysfunction (Child-Pugh class B or C). * Need for oral anticoagulation therapy. * Current or potential pregnancy. * Currently treated with strong CYP3A4 inhibitors. * Life expectancy \<1 year.
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What it tests

  • De-escalation strategy
  • Conventional strategy
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Where

1 site
DongA University Hospital
Busan, South Korea
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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