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Multidimensional Apathy in Psychiatric Pathologies.

RecruitingNAAges 18 Years - 60 YearsAllUniversity Hospital, Strasbourg, France
NCT04757220 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Apathy is defined by quantitative decrease in goal-directed activity in comparison to the person's previous level of functioning. Apathy is a transnosographic symptom, prevalent in many neurological and psychiatric pathologies (specifically in schizophrenia and depression), and almost half of patients suffer from it. It is an important source of burden, affecting both personal and occupational life. Despite its high prevalence and negative consequences, no pharmacological or non-pharmacological treatments exist, the underlying mechanisms of apathy being poorly understood. The main aim of the present study is to advance in our knowledge of cognitive and neural mechanisms of apathy by using a multidimensional model of apathy, distinguishing three forms: executive, emotional and auto-activation/initiative. the investigators hypothesize, independently of the pathology (schizophrenia and dep

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📋 Eligibility rules (as published)
Inclusion Criteria: * Inclusion criteria (all subjects): * age between 18 and 60 years * men or women volunteers, hospitalized or not * subject affiliated to an health insurance * subject having signed an informed consent Inclusion criteria (for schizophrenic patients): \- presence of DSM-V TR criteria for schizophrenia (American Psychiatric Association, 1994) Inclusion criteria (for depressive patients): \- presence of DSM-V TR criteria for depression (American Psychiatric Association, 1994) Exclusion Criteria: * a major or non stabilized somatic disorder * medical history likely to affect cerebral anatomy or linked to an abnormality (neonatal distress, neurochirurgical intervention, neurological disorders, stroke attack) * any disorders involved in the use of a psycho-active substance (as defined by the DSM-IV) * sensory disabling impairments, and specifically visual acuity \< 8 * general anaesthesia during the 3 months before the study * pregnancy (declared by the subject) * persons in an emergency situation * persons deprived in any way of their liberty * persons in period of exclusion in an other protocol Exclusion criteria (for controls): \- use of psychotropic substance during the 3 weeks before the study Exclusion criteria (for patients): \- use of benzodiazepines
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What it tests

  • Cognitive tasks with EEG recording
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Where

1 site
Service de Psychiatrie, Hôpital Civil, Hôpitaux Universitaires de Strasbourg
Strasbourg, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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