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Learning Study: Improving Vision in Adults With Macular Degeneration

RecruitingNAAges 18 Years - anyAllUniversity of Waterloo
NCT04762368 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to test whether a kind of brain stimulation called anodal transcranial direct current stimulation (a-tDCS) can be combined with perceptual learning to improve the ability of people with age-related macular degeneration (AMD) or juvenile macular degeneration (JMD) to read words presented to them on a computer screen better than if perceptual learning alone were used. In addition, secondary measures of visual acuity will also be examined to determine whether brain stimulation can allow patients to resolve finer details of an image. The proposed treatment is the application of a-tDCS onto the participant's head, with brain stimulation aimed at Primary Visual Cortex toward the occipital pole, while patients undergo six separate sessions of training. The investigators will test the ability of participants to read words before the start of the training sessions (p

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Diagnosis of AMD (age 60+) or JMD (current age 18+). 2. Visual acuity (VA); between 6/9-6/96 in the better eye 3. Best-corrected near visual acuity of 4.0M at 40 cm or better in the better eye 4. Stable vision in previous 3 months (patient report) 5. Central vision loss Exclusion Criteria: 1. Diagnosed dementia. 2. Not fluent in reading English (Waterloo) or Chinese characters (Hong Kong). 3. Any ocular surgery (including anti-vegF injections) within the duration of the study, except for: A. Chronic and continuous injections for at least 1 year. B. Injections stopped at least 2 months before participation. C. Injections in the untested eye 4. Ocular pathology other than JMD or AMD that can significantly reduce central vision. Example: mild cataract of grade 2 or below is acceptable 5. Severe hearing impairment. 6. Contraindications for brain stimulation
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What it tests

  • Active anodal tDCS
  • Sham anodal tDCS
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Where

2 sites
University of Waterloo
Waterloo, Canada
The Hong Kong Polytechnic University
Hung Hom, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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