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AERIAL Trial: Antiplatelet Therapy in Heart Transplantation

RecruitingPhase 3Ages 18 Years - anyAllOttawa Heart Institute Research Corporation
NCT04770012 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cardiac allograft vasculopathy is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. The research team is investigating whether early antiplatelet therapy post heart transplant can prevent the development of CAV. This study will determine the feasibility of a large multicenter randomized placebo-controlled trial to answer this question.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Heart transplant 2. Age ≥18 years 3. Able to provide informed consent Exclusion Criteria: 1. Allergy or known intolerance to aspirin 2. Allergy or known intolerance to clopidogrel 3. Intracranial hemorrhage ≤14 days 4. Bleeding disorder 5. Platelet count \<50 x 109/L 6. History of aspirin related gastrointestinal bleeding or ulcers 7. Non-cardiac indication for antiplatelet therapy 8. Anticoagulation \>3 months 9. Allergy to iodinated contrast 10. Unable to undergo coronary angiography due to glomerular filtration rate ≤30 mL/min/1.73 m2 for non-dialysis patients 11. Unable to undergo coronary angiography due to unsuitable vascular access 12. Combined solid organ transplantation.
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What it tests

  • Placebo
  • aspirin
  • Clopidogrel
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Where

3 sites
St.Pauls Hospital
Vancouver, Canada
University of Ottawa Heart Institute
Ottawa, Canada
Toronto General Hospital UHN
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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