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A Pilot Study of Non-invasive Brain Stimulation to Boost the Efficacy of Psychotherapy in a Community Sample of People Who Drink Alcohol

RecruitingPhase 2Ages 21 Years - 60 YearsAllThe Mind Research Network
NCT04770025 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this small (n=75) proof-of-concept randomized clinical trial is to test the effects of transcranial alternating current stimulation (tACS) during motivational interviewing (MI) sessions with participants who drink at above the low-risk level. Participants will be randomized to receive either MI with active stimulation, MI with sham stimulation, or a delayed treatment group that receives MI with no stimulation. Measures will include brain imaging, alcohol use, cannabis use, risk-taking behavior, emotions, and others. Participants who are randomized to the delayed-treatment group will not receive brain imaging.

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📋 Eligibility rules (as published)
Inclusion criteria: * Self-identify as having problem drinking * Right-handed * Age 21-60 years * AUDIT score indicating risky drinking Exclusion criteria: * Left-handed or ambidextrous * Currently engaged in treatment for alcohol use disorder * Receiving treatment for alcohol use disorder within the prior 12 months * History of brain injury or neurological diagnosis * Evidence of current psychosis * Past-year substance use disorder other than alcohol, marijuana, or nicotine * Current or history of severe alcohol withdrawal * MRI/tACS contraindications including pregnancy * Impaired hearing (psychotherapy using American Sign Language is not possible within the scope of the proposed study) * Insufficient corrected visual acuity to complete the assessment instruments * Unable to read/speak English fluently * Unable to provide valid informed consent
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What it tests

  • High-density transcranial alternating current stimulation
  • Sham stimulation
  • Motivational interviewing
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Where

1 site
The Mind Research Network
Albuquerque, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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