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A Safety, Tolerability, and Efficacy Study of VX-880 and VX-017 in Participants With Type 1 Diabetes

RecruitingPhase 3Ages 18 Years - 65 YearsAllVertex Pharmaceuticals Incorporated
NCT04786262 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will evaluate the safety, tolerability and efficacy of VX-880 infusion and VX-017 infusion in participants with type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.

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📋 Eligibility rules (as published)
Key Inclusion Criteria: * Clinical history of T1D with \>=5 years of duration of insulin dependence * At least two episodes of documented severe hypoglycemia in the 12 months prior to enrollment * Stable diabetic treatment * Consistent use of continuous glucose monitor (CGM) for at least 3 months before Screening and willingness to use CGM for the duration of the study Key Exclusion Criteria: -Prior islet cell transplant, organ transplant, or cell therapy Other protocol-defined Inclusion/Exclusion criteria may apply
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What it tests

  • VX-880
  • VX-017
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Where

29 sites
City of Hope
Duarte, United States
University of California San Francisco
San Francisco, United States
UHealth Diabetes Research Institute
Miami, United States
Northwestern Organ Transplant Center
Chicago, United States
University of Chicago
Chicago, United States
Johns Hopkins University
Baltimore, United States
Massachusetts General Hospital
Boston, United States
Hospital of the University of Pennsylvania
Philadelphia, United States

…and 21 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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