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Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.

RecruitingNAAges 18 Years - anyAllNaestved Hospital
NCT04806412 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Oncological treatment of patients with disseminated non-small cell lung cancer (NSCLC) is depending on the status of programmed death-ligand 1 (PD-L1), anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR), so called oncodrivers. These can be measured in pleural fluid, but the prevalence is uncertain. In a prospective study, the research team aim to measure PD-L1, ALK and EGFR in patients with pleural fluid cytology positive for NSCLC to report the prevalence. Also, the study will investigate if the chance of obtaining oncodriver status is depending on the volume analysed and how the lack of oncodrivers influence the following work-up.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Pleural effusion known or suspected of association with NSCLC (pleural fluid cytology positive for cells from NSCLC) * Patients must be able to give informed consent Exclusion Criteria: * Full oncodriver status measured in any pleural fluid in current work-up * Inability to understand written or spoken Danish.
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What it tests

  • meassurement of PD-L1, ALK, EGFR
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Where

1 site
Næstved Sygehus, department of pulmonary medicine
Næstved, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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