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Medial-prefrontal Enhancement During Schizophrenia Systems Imaging

RecruitingNAAges 18 Years - 64 YearsAllUniversity of California, San Francisco
NCT04807530 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated repetitive transcranial magnetic stimulation (nrTMS) target in the medial/superior prefrontal cortex (mPFC); and 3) how modulation of mPFC activity impacts the larger self-agency network to mediate changes in self-agency judgments. Our overall hypothesis is that increased mPFC excitability by active high-frequency nrTMS in HC and SZ will induce behavioral improvements in self-agency and neural changes in the larger self-agency network that will generalize to improvements in overall cognition, symptoms and daily functioning, and will likely lead to the development of new effective neuromodulation therapies in patients with schizophrenia.

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📋 Eligibility rules (as published)
Inclusion Criteria: All Subjects: * Good general physical health * English is first language * No neurological disorder * Meets MRI criteria * No current alcohol or substance use disorder Schizophrenia participants: * Schizophrenia diagnosis of any illness duration, * Clinical stability, defined as 12 weeks outpatient status and 4 weeks low to moderate dose of antipsychotic medication (\<1000 mg. chlorpromazine equivalents), plus stable doses of all other psychotropic medications Exclusion Criteria: All Subjects: * Implanted metallic parts of implanted electronic devices * Pregnant or trying to become pregnant * Any condition that would prevent the subject from giving voluntary informed consent * Scalp wounds or infections * Claustrophobia precluding MRI * Ongoing seizures * Neurological disorder
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What it tests

  • TMS
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Where

1 site
UCSF
San Francisco, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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