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Cognition and Motor Learning Post-stroke

RecruitingEARLY Phase 1Ages 45 Years - 85 YearsAllUniversity of Southern California
NCT04829071 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Unilateral stroke * Stroke occurred more than 6 months prior * Paresis confined to one side * Independently ambulatory (including the use of assistive devices) * Able to walk for 5 minutes without stopping * Answers no to all general health questions on the PAR-Q+ * Willingness to complete study procedures Exclusion Criteria: * Brainstem or cerebellar stroke * Aphasia (expressive, receptive, or global) * Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function * Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations * Uncontrolled hypertension (\>160/110mmHg) * Concurrent physical therapy * Claustrophobia * Significant cognitive deficit or dementia (\<20 on MoCA) * Inability to give informed consent
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What it tests

  • Explicit motor learning
  • Implicit motor learning
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Where

1 site
Center for Health Professions
Los Angeles, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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