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Genetic Epidemiology of Rotator Cuff Tears: The cuffGEN Study

Recruitingn/aAges 40 Years - 85 YearsAllUniversity of Michigan
NCT04831164 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Rotator cuff tear is one of the most common reasons to seek musculoskeletal care, and cuff repair is one of the fastest growing ambulatory surgery procedures. However, the etiology of cuff tears, reasons for variability treatment success, and causes of FI are poorly understood. A large-scale genome-wide association studies (GWAS) using imaging-verified rotator cuff tear cases and controls can address limitations in rigor of prior research and assess the genetic basis of FI and functional outcomes of cuff tear treatments. Primary Objective: To conduct a case-control GWAS of imaging-verified symptomatic rotator cuff tear in approximately 3000-6000 individuals and replicate findings in an independent set of 3000-6000 or more imaging-verified individuals to identify common variants in several genetic loci that increase risk for rotator cuff tears. Hypothesis: Common variants in several gen

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged ≥40 years to \< 85 years * Confirmed diagnosis of partial or full-thickness cuff tear on MRI (Cases) OR absence of rotator cuff tear on shoulder MRI (Controls) * Ability and willingness to provide informed consent * Ability to complete questionnaires in English (to maintain scientific integrity since standardized questionnaires are extensively validated in English) Exclusion Criteria: * Acute rotator cuff tear caused by a severe trauma
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What it tests

  • NA (not an interventional study)
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Where

10 sites
University of Iowa
Iowa City, United States
Brigham and Women's Hospital
Boston, United States
Boston Medical Center
Boston, United States
Beth Israel Deaconess Medical Center
Boston, United States
University of Michigan
Ann Arbor, United States
Ohio State University
Columbus, United States
Orthopedic Institute
Sioux Falls, United States
Vanderbilt University Medical Center
Nashville, United States

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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