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Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas

Recruitingn/aAges 50 Years - anyAllLeiden University Medical Center
NCT04832620 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Rationale: Chordomas and chondrosarcomas located in the axial skeleton are malignant neoplasms of bone. These tumors share the same clinical challenges, as the effect of the disease is more a function of their local aggressiveness than their tendency to metastasize (20% metastasize). The local aggressive behavior can cause debilitating morbidity and mortality by destruction of nearby located critical neurovascular structures. Imaging has, in addition to histopathology, a role in diagnosis and in guiding (neo)adjuvant and definitive treatment. Despite the low sensitivity to radiotherapy, proton radiotherapy has been successfully used as an adjunct to resection or as definitive treatment for aggressive chordomas and chondrosarcomas, making it a standard indication for proton therapy in the Netherlands. Chordomas and chondrosarcomas consist, especially after previous therapy, of non-viable

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically diagnosed with primary or recurrent chordoma or chondrosarcoma in the axial skeleton (clivus, spine and sacrum) * Accepted for standard proton beam therapy Exclusion Criteria: * Diagnosis other than chordoma or chondrosarcoma is made. * Patient refuses (parts) of the standard treatment protocol. * Patient refuses MRI due to claustrophobia. * Patient not suitable for MRI due to the presence of MRI incompatible implants. * Incapacitated patients. * Patient doesn't allow coded data to be used for analysis. * Patient is under 50 years of age. * Lesion size less than 1cm. * Patients with WHO 3 and higher.
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What it tests

  • Not listed
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Where

2 sites
HollandPTC
Delft, Netherlands
LUMC
Leiden, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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