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Multi-layer Data to Improve Diagnosis, Predict Therapy Resistance and Suggest Targeted Therapies in HGSOC

RecruitingNAAges 18 Years - anyFemaleTurku University Hospital
NCT04846933 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chemotherapy resistance is the greatest contributor to mortality in advanced cancers and severe challenges remain in finding effective treatment modalities to cancer patients with metastasized and relapsed disease. High-grade serous ovarian cancer (HGSOC) is typically diagnosed at a stage where the disease is already widely spread to the abdomen and current standard of practice treatment consists of surgery followed by platinum-taxane based chemotherapy and maintenance therapy. While 90% of HGSOC patients show no clinically detectable signs of cancer after surgery and chemotherapy, only 43% of the patients are alive five years after diagnosis because of chemoresistant cancer. This prospective, observational trial focuses on revealing major mechanisms causing chemoresistance in HGSOG patients and derive personalized treatment regimens for chemotherapy resistant HGSOC patients. The invest

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with a suspected ovarian cancer diagnosis treated at the Turku University Hospital * Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: * Age \<18 years, too poor condition for active treatment (surgery, chemotherapy) * FDG PET/CT scan is not performed for patients with diabetes mellitus and poor glucose balance.
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What it tests

  • WGS and RNA sequencing
  • circulating tumor DNA (ctDNA)
  • FDG PET/CT imaging
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Where

1 site
Turku University Hospital
Turku, Finland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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