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Sympathetic Nerve Activity Predictors in Patients With Chronic Obstructive Pulmonary Disease

Recruitingn/aAges 18 Years - anyAllRWTH Aachen University
NCT04849806 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen University Hospital; Head of Department: Professor Michael Dreher). Overactivity of the sympathetic nerve activity (SNA) axis with "centrally" increased heart rate and peripheral vasoconstriction is a known phenomenon in patients with systolic heart failure (HF) and has recently been described in patients with primary lung disease as seen in chronic obstructive pulmonary disease (COPD). However, systematic analyses on this clinically relevant topic are currently lacking. Thus, using a comprehensive, multimodal approach and state-of-the-art technology, this research project is designed to determine the extent and nature of increased SNA in COPD (AIM 1) and evaluate t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 * Ability and willingness to give informed consent to participate in the study Exclusion Criteria: * Atrial fibrillation * Active pacing of the heart by a cardiac pacemaker (i.e. no intrinsic heart rate) * Clinically pre-established cardiovascular disease (e.g. arterial hypertension or systolic heart failure) * In-patient stay in the hospital within the last 4 weeks prior to the study examination date
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What it tests

  • Assessments of the sympathetic nerve activity axis
  • OSA severity
  • Determination of PH and right HF severity
  • Comprehensive lung function and inspiratory muscle function testing.
  • Assessment of systemic inflammation
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Where

1 site
RWTH Aachen University
Aachen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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