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EREctile Function Preservation for Prostate Cancer Radiation Therapy (ERECT)

RecruitingNAAges 18 Years - anyMaleUMC Utrecht
NCT04861194 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Single-arm phase II trial of 70 men with low- or intermediate-risk prostate cancer receiving magnetic resonance guided adaptive radiotherapy (MRgRT) in 5 fractions of 7.25 Gy, additionally sparing the neurovascular bundles, the internal pudendal arteries, the corpora cavernosa, and the penile bulb for erectile function preservation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years * Histologically proven adenocarcinoma of the prostate * Low-risk or intermediate-risk prostate cancer according to NCCN risk categories (low risk: T1c-T2a, Gleason score ≤6, and PSA \<10 µg/L; intermediate risk: T2b-T2c or Gleason score 7 or PSA 10-20 µg/L) * Patients with pT1a/b tumor diagnosis after transurethral resection of the prostate (TURP) * Domain score of 17-25 on the International Index of Erectile Function-5 (IIEF-5) questionnaire * Karnofsky score of 70-100 * Written informed consent Exclusion Criteria: * Use of (neo-)adjuvant androgen deprivation therapy * High-risk prostate cancer according to NCCN risk categories (T3a or Gleason score 8-10 or PSA \>20 µg/L) * Patients with "bulky" iT3 tumor diagnosis * Previous pelvic irradiation or radical prostatectomy * Clinical evidence of metastatic disease * Patients who are unable to undergo MRI * Patients who are incompetent to sign written informed consent
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What it tests

  • Neurovascular-sparing
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Where

1 site
University Medical Center Utrecht
Utrecht, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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