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Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia

RecruitingNAAges 18 Years - 60 YearsAllCentre Hospitalier Universitaire de Saint Etienne
NCT04871048 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cannabis use disorder is a frequent comorbidity of schizophrenia, associated with increased symptoms and less adherence to therapy. Validated care has limited effectiveness in this population and development of new management strategies seems necessary. Transcranial direct current stimulation (tDCS) has shown beneficial effects in both schizophrenia, substance use disorder and, in a less extent, in nicotine addiction in schizophrenic subjects. It is interesting to test if that 10 sessions of anodal stimulation of the right dorsolateral prefrontal cortex (DLPFC) and cathodal stimulation of the medial prefrontal cortex (MPFC) (by increasing control and modulating reward system), will reduce, in 110 schizophrenic subjects, cannabis consumption, and secondly craving, addiction severity, schizophrenic symptoms and improve global functioning. It is possible that these clinical effects will be

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📋 Eligibility rules (as published)
Inclusion Criteria: * Schizophrenia diagnostic according to DSM (Diagnostic and Statistical Manual of mental disorder) 5 criteria, without change in psychotropic treatment since at least 4 weeks * Moderate to severe cannabis use disorder according to DSM 5 criteria and active consumption during the last 7 days * Subjects motivated to reduce or quit their cannabis consumption * Patients with ambulatory compulsory care may be included Exclusion Criteria: * Other substance use disorder, excluding nicotine, according to DSM 5 criteria * Other current psychiatric disorder according to DSM 5 criteria, excluding personality disorder * Inpatient hospitalization * History of head injury, neurological disorder with cerebral consequence or severe unstable somatic disorder * Pregnancy or no contraception * Contraindications for tDCS and/or MRI (implanted material, uncontrolled epilepsy, intracranial hypertension)
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What it tests

  • Transcranial direct current stimulation (tDCS) active
  • Transcranial direct current stimulation (tDCS) non active
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Where

8 sites
CH Le Vinatier Service universitaire d'addictologie de Lyon
Bron, France
Centre Hospitalier Universitaire Service d'Addictologie et Pathologies Duelles
Clermont-Ferrand, France
CHU de Clermont-Ferrand Service de Psychiatrie
Clermont-Ferrand, France
Service Hospitalo-Universitaire d'Addictologie CHU de Dijon
Dijon, France
CHU Pôle de Psychiatrie Neurologie et Rééducation
La Tronche, France
CH Saint-Cyr-au-Mont-d'Or service de psychiatrie
Saint-Cyr-au-Mont-d'Or, France
Centre Hospitalier Alpes Isère
Saint-Égrève, France
CHU de Saint-Etienne
Saint-Priest-en-Jarez, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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