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Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenström Macroglobulinemia

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Universitaire, Amiens
NCT04893564 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Waldenström Macroglobulinemia (WM) is defined by a bone marrow lymphoplasmacytic infiltration and the presence of a monoclonal immunoglobulin M (IgM) in blood. This chronic lymphoproliferative disorder requires treatment only in case of symptoms, according to accurate criteria described during the second Workshop on WM i.e. in case of cytopenia, bulky organomegaly, immunological or physicochemical consequences of the presence of IgM in circulating blood. A MYD88 mutation, typically a MYD88(L265P), is found in 90% of WM patients. Other gene abnormalities have been observed, the most frequent is a mutation in the CXCR4 gene. Overall, gene mutations in WM involve only a limited number of signalling pathways, yielding the activation of NFkB, namely : the TLR and MYD88 pathway (with an activation of NFkB and BTK in case of MYD88(L265P) mutation), the BCR pathway (involving btk and associated

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient with WM according to diagnostic criteria * Patients with WM followed in one of the centre of North-Western region. * Patients requiring first-line or subsequent-line therapy * Patients agreement for giving informed consent. * Social insurance system affiliation Exclusion Criteria: * Patients with another chronic B-cell malignancy * patients with other lymphoplasmacytic proliferations * patients with marginal zone lymphoma. * Patients with WM and histologic transformation * Absence of informed consent
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What it tests

  • bone marrow sample
  • blood sample
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Where

1 site
CHU Amiens
Amiens, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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