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Phenylalanine-free Diet for Patients With Secondary Hyperphenylalaninemia in ICU

RecruitingNAAges 20 Years - anyAllChang Gung Memorial Hospital
NCT04896281 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hyperphenylalaninemia is not only present in patients with congenital phenylketonuria. In adults with critical illness, hyperphenylalaninemia is noted in some patients and is associated with high mortality rate. Hyperphenylalaninemia can cause metabolic acidosis, brain dysfunction, and metabolic disturbance. The investigators would like to see whether the phenylalanine-free milk for congenital phenylketonuria is also effective in lowering the blood phenylalanine concentrations in patients with critical illness in intensive care unit and hyperphenylalaninemia.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. had Acute Physiology And Chronic Health Evaluation (APACHE II) scores of ≥15; 2. were expected to stay in the ICU \>48 hours; 3. patients with baseline PHE levels of ≥95 uM; 4. were over 20 years old. Exclusion Criteria: 1. patients with comorbid disorders other than the main cause for admission that might compromise their survival within three months, such as terminal stage cancer; 2. patients with expected survival \<3 days.
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What it tests

  • Phenylalanine-free milk
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Where

1 site
Chang Gung Memorial Hospital
Keelung, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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