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Measles and BCG Vaccines for Mother and Child

RecruitingPhase 4Ages 15 Years - 35 YearsFemaleBandim Health Project
NCT04899765 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In Africa, the mortality from infectious diseases remains high. The investigators have discovered that live vaccines such as the BCG vaccine against tuberculosis and the measles vaccine can strengthen resistance to other infections: they have beneficial "non-specific effects". The investigators have now seen signs that these non-specific effects for children are stronger if their mother has been given the same vaccines. In Africa, BCG vaccine is recommended at birth and measles vaccine at 9 months of age. They are not used beyond childhood. The investigators will randomize 2400 women to BCG vaccine, measles vaccine, or placebo. The investigators will further randomize their children to an extra early measles vaccine or placebo. The investigators will assess which of the resulting six vaccination schedules are best for women's and children's protection against measles, for the child's i

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female women in the fertile age * Non-pregnant * HIV-negative * Living in the BHP HDSS study area * Delivered a child that has reached 12 months of age * Currently not using contraceptives. Exclusion Criteria: * Positive pregnancy test * Positive HIV test * Tuberculosis (previous or current) * Immunodeficiency * Cancer within the last 2 years * Mid-upper-arm-circumference\<200 * Acute ongoing infection
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What it tests

  • BCG vaccine
  • Measles vaccine
  • Placebo
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Where

1 site
Bandim Health Project
Bissau, Guinea-Bissau
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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