Intrathecal Chemotherapy for Central Nervous System Metastasis in Retinoblastoma

Inclusion Criteria: * The pathological diagnosis was retinoblastoma. According to the IRSs (International retinoblastoma staging system) staging system, the stage was IVB * CSF tumor cells on cytology, or radiographic evidence of NM on MRI scans and histologic diagnosis of systemic malignancy needed * KPS≥60% * Adequate bone marrow and organ function * The parents signed the informed consent and were willing to accept the treatment and follow-up. Exclusion Criteria: * 1.Eye diseases other than retinoblastoma * The eyes were infected within 30 days before screening * There was a history of surgery and / or unhealed wound within 1 month before enrollment . * Those who have allergic reaction or allergic history to chemotherapeutic drugs. * Infectious diseases requiring oral, intramuscular or intravenous administration. * Patients with systemic immune diseases. * Active disseminated intravascular coagulation. * Abnormal coagulation function. * Abnormal bone marrow and organ function. * Uncontrollable clinical problems. * The researchers believe that those who need to be excluded.