🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Efficacy of Preventive Ketamine on Postoperative Pain

RecruitingPhase 4Ages 21 Years - 60 YearsAllAin Shams University
NCT04908579 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

* Although bariatric surgery is mainly performed laparoscopically, analgesic optimization is still essential to reduce complications and to improve the patients' comfort. In laparoscopic sleeve gastrectomy, the intraoperative peritoneal instillation of bupivacaine hydrochloride (30 ml, 0.25%) was known to be safe and effective in reducing postoperative pain, nausea, and vomiting. * Furthermore, usage of ketamine both as a pre and post-operative pain management is well established. Ketamine can be used solely or in combination with other co-adjuvant drugs, increasing their efficacy. Many therapeutic properties of ketamine have been attributed to its antagonism mechanism to N-Methyl-D-aspartate receptors.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * \- Body mass index \> 35 and \< 60 kg/m2 * Either medically free or with well controlled hypertension and/or diabetes. Exclusion Criteria: * \- Patient's refusal to participate in the study * BMI \> 60 kg/m2. * Age less than 21 years. * Patients with severe systemic disease which is not life-threatening. * Patients on antipsychotics, antidepressants and/or corticosteroids. * Patients with history of obstructive sleep apnea. * Allergic reaction to any of the study medications.
💊

What it tests

  • bupivacaine(intraperitoneally) and ketamine (intraperitoneally)
  • bupivacaine(intraperitoneally) and ketamine (intravenously)
  • bupivacaine(intraperitoneally)
📍

Where

1 site
Ain-Shams University Hospitals
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy