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PEEP in Patients With Acute Respiratory Failure

Recruitingn/aAges 18 Years - anyAllJesus Villar
NCT04912960 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support. In 1975, several investigators published the effects of PEEP in 15 mechanically ventilated patients with acute respiratory failure (ARF) supported by mechanical ventilation. FiO2 ranged between 21% to 75% and the tidal volume between 13 to 15 mL/kg. PEEP was increased in 3 cmH2O steps until cardiac output fell. The aim was to identify the "optimum" PEEP level. "Best" PEEP was associated simultaneously with the best static compliance of the respiratory system, the greatest oxygen transport, and the lowest dead space fraction. That study established the basis for the use of PEEP in patients with ARF worldwide. Although currently patients with ARF are ventilated with much lower tidal volumes, that study has never been validated. It is unknow wheth

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📋 Eligibility rules (as published)
Inclusion Criteria: * Intubated patients requiring MV for \>24 h * Age \>18 years * Acute hypoxemic respiratory failure, defined as a PaO2/FiO2 \<300 with an FiO2 ≥0.3 and PEEP≥5 cmH2O. * ARF caused by pulmonary insults. Exclusion Criteria: * ARF from non-pulmonary origin. * Contraindications from high PEEP (severe head trauma or severe chest trauma). * Patients that cannot maintained supine position. * Uncorrected hypovolemia * Hemodynamic instability
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What it tests

  • Mechanical ventilation
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Where

3 sites
Hospital Universitario Dr. Negrin
Las Palmas de Gran Canaria, Spain
Hospital Clinic
Barcelona, Spain
Hospital Universitario La Princesa
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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