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Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries

RecruitingPhase 4Ages 21 Years - 50 YearsAllDamanhour Teaching Hospital
NCT04914234 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries. Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding. Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.

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📋 Eligibility rules (as published)
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status ≤ II * Age from 21 to 50 years Exclusion Criteria: * ASA physical status \> II * Age \< 21 years or \> 50 years * Pregnant women * Breastfeeding * Bronchial asthma * Chronic obstructive pulmonary disease * Diabetes Mellitus * Hypertension * Ischemic heart disease * Rheumatic heart disease * Heart failure * Heart block * Sick sinus syndrome * Sinus bradycardia * Chronic hypotension * Anemia (Hb \< 10 g/dl) * Renal or hepatic dysfunction * Central nervous system disease * Allergic fungal sinusitis * Patients on beta-blockers * Alcohol or drug abuse * Anticoagulation therapy, * Bleeding diathesis * Agents influencing autonomic nervous system * Allergy to the study drugs * Any contraindication of oral intake
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What it tests

  • Atenolol Succinate Oral Tablet
  • Metoprolol Succinate Oral Tablet
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Where

1 site
Damanhour Teaching Hospital
Damanhūr, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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