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Faecal Microbiota Transplantation for Liver Cirrhosis

RecruitingPhase 2, Phase 3Ages 18 Years - 75 YearsAllUniversity of Aarhus
NCT04932577 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis. Further, the investigators want to examine the impact of FMT on the gut microbiota, gut barrier function, systemic inflammation, and immune function.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-75 years * Liver cirrhosis with Child-Pugh ≤ 12 * Acute decompensation requiring intervention (ascites, gastrointestinal bleeding, infections leading to progressive liver failure, overthepatic encephalopathy, alcoholic hepatitis) Exclusion Criteria: * More than one organ failure defined by CLIF-SOFA score * Untreated malignancy apart from non-melanoma skin cancer * Untreated viral hepatitis * HIV * Inflammatory bowel disease * Celiac disease * Clostridioides Difficile infection * Pregnancy * Unable to participate based on medical judgement
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What it tests

  • Faecal microbiota transplantation
  • Placebo
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Where

1 site
Department of Hepatology and Gastroenterology, Aarhus University Hospital
Aarhus, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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