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ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions

RecruitingNAAges 18 Years - anyAllMontreal Heart Institute
NCT04936607 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The NEPTUNE triple-blind, active-placebo, adaptive, pragmatic, randomized trial aims to evaluate the effectiveness of a new intra-venous hydration strategy guided by left ventricular end-diastolic pressure (LVEDP), amount of contrast used, and baseline renal function, to prevent contrast-induced acute kidney injury (CI-AKI) and patient-oriented clinical endpoints in all-comer patients undergoing coronary angiogram and/or percutaneous coronary intervention (PCI).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years; * Planned coronary angiogram and/or PCI; * Willingness to participate and to attend study visits; * Expected life expectancy ≥6 months. Exclusion Criteria: * Cardiogenic or non-cardiogenic shock at the time of the procedure; * Emergent procedures (e.g. STEMI); * Iodine-based contrast media received within 2 days; * Presence of Intra-Aortic Balloon Pump (IABP); * Cardiac arrest within 24 hours; * Pre-procedural AKI defined using the modified KDIGO criteria within 7 days; * Renal replacement therapy; * Severe aortic or mitral disease; * LVEF \<30%.
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What it tests

  • Personalized hydration strategy
  • Standard of care
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Where

1 site
Montreal Heart Institute
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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