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Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

RecruitingNAAges 18 Years - 55 YearsAllMassachusetts General Hospital
NCT04940663 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. 18-55 years old 2. Experienced a psychotic disorder or mood disorder Exclusion Criteria: 1. Any neurological disorder or current substance use disorder (during the past 6 months) 2. Not proficient in English 3. A recent change in medication, or an acute symptom presentation 4. Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).
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What it tests

  • EMA
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Where

1 site
Massachusetts General Hospital
Charlestown, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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