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EUS-CPN With and Without Bupivacaine

RecruitingNAAges 18 Years - anyAllCentre hospitalier de l'Université de Montréal (C…
NCT04951804 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Endoscopic ultrasound (EUS) allows EUS-guided trans gastric injection of absolute alcohol around the base of the celiac plexus (celiac plexus neurolysis (EUS-CPN)), to help alleviate pain associated with pancreatic cancer. It is standard procedure to inject bupivacaine immediately before injecting absolute alcohol, to theoretically prevent pain that may occur during and after the procedure. However, there are no data showing whether bupivacaine injection has any real influence on intra-procedural, immediate post-procedural, or long-term pain control. The injection of bupivacaine before the alcohol may have no effect, a synergistic effect, or an antagonistic effect, by diluting the alcohol, and reducing its neurolytic capacity. Inadvertent intravascular injection of bupivacaine may also cause irreversible cardiac arrhythmias and death. The investigators therefore propose a randomized cl

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Malignant-appearing pancreatic mass, or proven pancreatic cancer involving the pancreatic genu, body, or tail 2. Any level of abdominal or back pain considered to be potentially related to the mass: 1. New onset pain (\<3 months) 2. Constant 3. Centrally located 4. With or without irradiation to the back 5. No obvious other source of pain based on history and physical examination by the attending endosonographer 3. No possibility of surgical management 4. Signed, informed consent 5. Celiac axis accessible for bilateral neurolysis at EUS. Exclusion Criteria: 1\. Allergy to bupivacaine
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What it tests

  • EUS-CPN without bupivacaine
  • EUS-CPN with bupivacaine
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Where

1 site
Centre de recherche du Centre hospitalier de l'Université de Montréal
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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