Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

Inclusion Criteria: * Able to understand and comply with the study procedures, understand the risks involved in the study, and provide legally effective informed consent before the first study-specific procedure; specifically able to comply with the PK assessment schedule during the first treatment cycle. * Participants must have a histologically or cytologically confirmed malignancy as follows: 1. A solid tumor that is metastatic or unresectable and for which standard life-prolonging measures are not available. or 2. AML or MDS. or 3. A hematologic malignancy other than AML or MDS for which standard life-prolonging measures are not available. * For participants with AML/MDS only: 1. Cytologically or histologically confirmed diagnosis of AML (except M3 acute promyelocytic leukemia) or MDS according to the 2008 World Health Organization (WHO) classification; or 2. Participants with frontline MDS or treatment naïve AML not suitable for induction therapy (e.g., \>75 years, Eastern Cooperative Oncology Group \[ECOG\] performance status ≥2, severe pulmonary disorder, total bilirubin \>1.5X ULN; and 3. Platelet count ≥25,000/per microliter (μ); and 4. Absolute neutrophil count (ANC) ≥100 cells/μL. * For participants only with hematologic malignancies other than AML or MDS, or with solid tumors: 1. Platelet count ≥100,000/μL; and 2. ANC ≥1000 cells/μL. * ECOG performance status of 0 to 3. * Hepatic function defined per the National Cancer Institute Cancer Therapy Evaluation Program (NCI CTEP) Organ Dysfunction Working Group (ODWG) as: 1. Normal hepatic function (Group A): total bilirubin ≤1× ULN; aspartate aminotransferase (AST): ≤1× ULN; 2. Moderate hepatic impairment (Group B): total bilirubin \>1.5 to 3 × ULN; AST: any value; 3. Severe hepatic impairment (Group C): total bilirubin \>3 × ULN; AST: any value. * Adequate renal function defined as creatinine clearance (CLcr, \>50 mL/min according to the Cockcroft-Gault equation): CLcr (mL/min) = \[(140-age(years)\] × weight (in kg)/ 72 × serum creatinine (in mg/dL)) × 0.85 \[if female\] * No major surgery within 30 days of first administration of oral decitabine and cedazuridine. * Life expectancy of at least 3 months. * Women of childbearing potential (according to recommendations of the Clinical Trial Facilitation Group) must not be pregnant or breastfeeding and must have a negative pregnancy test at screening. * Women of childbearing potential must agree to practice 1 highly effective contraceptive measure of birth control with low user dependency and must agree not to become pregnant for 6months after completing treatment * Male participants with female partners of childbearing potential must agree to use a male condom and advise his partner to practice 1 highly effective contraceptive measure of birth control (user dependent or with low user dependency) and must agree not to father a child while receiving treatment with oral decitabine and cedazuridine and for at least 3 months after completing treatment. Exclusion Criteria: * Treatment with azacitidine or decitabine within 4 weeks before screening. Prior cytotoxic chemotherapy for AML except for hydroxyurea to control high white blood cell (WBC) counts. * Hospitalization for more than 2 days for documented febrile neutropenia, pneumonia, sepsis, or systemic infection 30 days prior to first dose. * Treatment with any investigational medicinal product (IMP), investigational therapy, chemotherapy, immunotherapy, or targeted therapy within 2 weeks or 5 half-lives, whichever is longer, before the first dose of study treatment, or ongoing clinically significant adverse events from previous treatment. * Concurrent MDS therapies, including lenalidomide, erythropoietin, cyclosporine/tacrolimus, granulocyte-colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor, etc. Prior treatment with these agents is permitted, provided that completion is at least 1 week before the first dose of study treatment. Short-term use of G-CSF for febrile neutropenia is permitted at the discretion of the treating physician and should be guided by accepted practice or institutional guidelines. Hematopoietic growth factors will not be routinely used unless cleared by Taiho medical expert. * Administration of live (attenuated) vaccines within 4 weeks before the first administration of oral decitabine and cedazuridine until after the follow-up visit. Other vaccines, e.g., inactivated or ribonucleic acid (RNA)-based, may be administered but should not occur from 7 days before first administration of oral decitabine and cedazuridine until after the follow-up visit. * High medical risk because of other conditions such as uncontrolled systemic diseases, active uncontrolled infections, or comorbidities that may put the participant at risk of not being able to complete 1 cycle of treatment. * Conditions which likely promote delayed ventricular repolarization (QT prolongation): 1. QTc using Fridericia's correction (QTcF) at screening or Day -1 \>470 ms for males and \>480 ms for females. or 2. History or disposition for torsades des pointes (TdP) (e.g., heart failure, hypokalemia, family history of long QT Syndrome). or 3. Concomitant medications that prolong the QT/QTc interval. * Cardiac abnormalities or unstable cardiovascular conditions: 1. Unstable ischemic heart disease or severe heart failure (New York Heart Association Class III or IV). or 2. Uncontrolled treated/untreated hypertension (defined as a mean of 3 repeated measurements for systolic blood pressure ≥180 millimeters of mercury (mmHg) and/or diastolic blood pressure ≥110 mmHg; current or documented history of repeated clinically significant hypotension or severe episodes of orthostatic hypotension (systolic blood pressure \<90 mmHg and/or diastolic blood pressure \<50 mmHg). * Known significant mental illness or other condition, such as active alcohol or other substance