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Natural History of KSHV-Associated Multicentric Castleman s Disease

Recruitingn/aAges 18 Years - anyAllNational Cancer Institute (NCI)
NCT04968288 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Kaposi s sarcoma herpes virus (KSHV) causes several kinds of cancer, Kaposi sarcoma (KS), a form of Multicentric Castleman s Disease (MCD) and a type of lymphoma known as Primary Effusion Lymphoma (PEL). These cancers can occur alone or at the same time in the same patient. MCD can cause a lot of symptoms and problems with various organs in the body, making patients feel quite unwell. If unrecognized, the disease can be fatal. Medications such as rituximab alone or in combination with chemotherapy may help treat MCD but there is little known about the long term effects and the natural course of MCD. Objective: To better understand the biology of KSHV-MCD to help identify how this disease causes illness and how cancer treatments known to be effective in MCD may help patients with this condition. This study also aims to help identify ways to treat the disease by providing ot

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: * Biopsy proven KSHV-associated MCD, confirmed in the Laboratory of Pathology (LP), CCR * Age \>=18 years. * ECOG performance status \<=4 (Karnofsky \>=20%). * Ability of subject to understand and the willingness to sign a written informed consent document. * Participants may be co-enrolled in other protocols, including investigational studies to treat KSHV-associated malignancies. EXCLUSION CRITERIA: * Any condition or set of circumstances that in the opinion of the investigators would make participation in this study unsafe or otherwise inappropriate for a given individual. * Pregnancy
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What it tests

  • Not listed
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Where

1 site
National Institutes of Health Clinical Center
Bethesda, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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