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Using Nicotine to Reverse Age-related Auditory Processing Deficits

RecruitingNAAges 18 Years - 85 YearsAllUniversity of California, Irvine
NCT04971954 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.

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📋 Eligibility rules (as published)
Inclusion Criteria: * between 18 and 85 years of age * non-smokers with a score of 0-2 out of 10 maximum on the Fagerström index of smoking dependency * cognitive performance within two standard deviations of the CERAD mean Exclusion Criteria: * less than 18 or greater than 85 years of age * deafness or excessive hearing loss * smokers with a score between 3 and 10 on the Fagerström index of smoking dependency * history of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease * regular use of prescription medications (excluding oral contraceptives) * drug dependency
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What it tests

  • Nicotine gum
  • Placebo gum
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Where

2 sites
Hearing and Speech Lab
Irvine, United States
San Diego State University
San Diego, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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