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EUS-RFA PANCARDINAL-1 Trial

RecruitingPhase 2Ages 18 Years - anyAllThe University of Texas Health Science Center, Ho…
NCT04990609 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The objectives of this study are to determine the feasibility, tolerability, and treatment effect of endoscopic ultrasound (EUS) radiofrequency ablation (RFA) plus standard-of-care neoadjuvant chemotherapy (NAC) in the treatment of pancreatic ductal adenocarcinoma (PDAC). Endoscopic ultrasound (EUS) radiofrequency ablation (RFA) and neoadjuvant chemotherapy (NAC) will be performed before tumor resection surgery, with the goal of shrinking a tumor or stopping the spread of cancer so that surgery might be less invasive and more effective.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosed and histologically-confirmed PDAC by biopsy * Permanent street address * Consent to study participation * Axial CT scan consistent with PDAC * No prior chemotherapy or less than 2 months of pre-operative chemotherapy for PDAC * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 Exclusion Criteria: * Male or female patients \< 18 years of age * No permanent street address or telephone number * Pregnant patients * Inmates or prisoners * Unable to provide informed consent
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What it tests

  • Endoscopic Ultrasound (EUS)-Guided Radiofrequency Ablation (RFA)
  • Neoadjuvant Chemotherapy (NAC)
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Where

1 site
Memorial Hermann Hospital
Houston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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